Single amino acid changes in the 6K1-CI region can promote the alternative adaptation of Prunus- and Nicotiana-propagated Plum pox virus C isolates to either host.
Identifieur interne : 000195 ( Main/Exploration ); précédent : 000194; suivant : 000196Single amino acid changes in the 6K1-CI region can promote the alternative adaptation of Prunus- and Nicotiana-propagated Plum pox virus C isolates to either host.
Auteurs : María Calvo ; Tadeusz Malinowski ; Juan Antonio GarcíaSource :
- Molecular plant-microbe interactions : MPMI [ 0894-0282 ] ; 2014.
Descripteurs français
- KwdFr :
- ADN complémentaire (génétique), ARN viral (génétique), Feuilles de plante (virologie), Génome viral (génétique), Interactions hôte-pathogène (MeSH), Maladies des plantes (virologie), Protéines virales (génétique), Protéines virales (métabolisme), Prunus (virologie), Spécificité d'hôte (MeSH), Substitution d'acide aminé (MeSH), Tabac (virologie), Virus de la variole du prunier (génétique), Virus de la variole du prunier (pathogénicité), Virus de la variole du prunier (physiologie).
- MESH :
- génétique : ADN complémentaire, ARN viral, Génome viral, Protéines virales, Virus de la variole du prunier.
- métabolisme : Protéines virales.
- pathogénicité : Virus de la variole du prunier.
- physiologie : Virus de la variole du prunier.
- virologie : Feuilles de plante, Maladies des plantes, Prunus, Tabac.
- Interactions hôte-pathogène, Spécificité d'hôte, Substitution d'acide aminé.
English descriptors
- KwdEn :
- Amino Acid Substitution (MeSH), DNA, Complementary (genetics), Genome, Viral (genetics), Host Specificity (MeSH), Host-Pathogen Interactions (MeSH), Plant Diseases (virology), Plant Leaves (virology), Plum Pox Virus (genetics), Plum Pox Virus (pathogenicity), Plum Pox Virus (physiology), Prunus (virology), RNA, Viral (genetics), Tobacco (virology), Viral Proteins (genetics), Viral Proteins (metabolism).
- MESH :
- chemical , genetics : DNA, Complementary, RNA, Viral, Viral Proteins.
- genetics : Genome, Viral, Plum Pox Virus.
- chemical , metabolism : Viral Proteins.
- pathogenicity : Plum Pox Virus.
- physiology : Plum Pox Virus.
- virology : Plant Diseases, Plant Leaves, Prunus, Tobacco.
- Amino Acid Substitution, Host Specificity, Host-Pathogen Interactions.
Abstract
Plum pox virus (PPV) C is one of the less common PPV strains and specifically infects cherry trees in nature. Making use of two PPV-C isolates that display different pathogenicity features, i.e., SwCMp, which had been adapted to Nicotiana species, and BY101, which had been isolated from cherry rootstock L2 (Prunus lannesiana) and propagated only in cherry species, we have generated two infective full-length cDNA clones in order to determine which viral factors are involved in the adaptation to each host. According to our results, the C-P3(PIPO)/6K1/N-CI (cylindrical inclusion) region contains overlapping but not coincident viral determinants involved in symptoms development, local viral amplification, and systemic movement capacity. Amino acid changes in this region promoting the adaptation to N. benthamiana or P. avium have trade-off effects in the alternative host. In both cases, adaptation can be achieved through single amino acid changes in the NIapro protease recognition motif between 6K1 and CI or in nearby sequences. Thus, we hypothesize that the potyvirus polyprotein processing could depend on specific host factors and the adaptation of PPV-C isolates to particular hosts relies on a fine regulation of the proteolytic cleavage of the 6K1-CI junction.
DOI: 10.1094/MPMI-08-13-0242-R
PubMed: 24200075
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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(virologie)</term><term>Génome viral (génétique)</term><term>Interactions hôte-pathogène (MeSH)</term><term>Maladies des plantes (virologie)</term><term>Protéines virales (génétique)</term><term>Protéines virales (métabolisme)</term><term>Prunus (virologie)</term><term>Spécificité d'hôte (MeSH)</term><term>Substitution d'acide aminé (MeSH)</term><term>Tabac (virologie)</term><term>Virus de la variole du prunier (génétique)</term><term>Virus de la variole du prunier (pathogénicité)</term><term>Virus de la variole du prunier (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>DNA, Complementary</term><term>RNA, Viral</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Genome, Viral</term><term>Plum Pox Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ADN complémentaire</term><term>ARN viral</term><term>Génome viral</term><term>Protéines virales</term><term>Virus de la variole du prunier</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Plum Pox Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la variole du prunier</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la variole du prunier</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Plum Pox Virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Feuilles de plante</term><term>Maladies des plantes</term><term>Prunus</term><term>Tabac</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Plant Diseases</term><term>Plant Leaves</term><term>Prunus</term><term>Tobacco</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Substitution</term><term>Host Specificity</term><term>Host-Pathogen Interactions</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Interactions hôte-pathogène</term><term>Spécificité d'hôte</term><term>Substitution d'acide aminé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Plum pox virus (PPV) C is one of the less common PPV strains and specifically infects cherry trees in nature. Making use of two PPV-C isolates that display different pathogenicity features, i.e., SwCMp, which had been adapted to Nicotiana species, and BY101, which had been isolated from cherry rootstock L2 (Prunus lannesiana) and propagated only in cherry species, we have generated two infective full-length cDNA clones in order to determine which viral factors are involved in the adaptation to each host. According to our results, the C-P3(PIPO)/6K1/N-CI (cylindrical inclusion) region contains overlapping but not coincident viral determinants involved in symptoms development, local viral amplification, and systemic movement capacity. Amino acid changes in this region promoting the adaptation to N. benthamiana or P. avium have trade-off effects in the alternative host. In both cases, adaptation can be achieved through single amino acid changes in the NIapro protease recognition motif between 6K1 and CI or in nearby sequences. Thus, we hypothesize that the potyvirus polyprotein processing could depend on specific host factors and the adaptation of PPV-C isolates to particular hosts relies on a fine regulation of the proteolytic cleavage of the 6K1-CI junction. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24200075</PMID><DateCompleted><Year>2014</Year><Month>04</Month><Day>03</Day></DateCompleted><DateRevised><Year>2014</Year><Month>01</Month><Day>08</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0894-0282</ISSN><JournalIssue CitedMedium="Print"><Volume>27</Volume><Issue>2</Issue><PubDate><Year>2014</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Molecular plant-microbe interactions : MPMI</Title><ISOAbbreviation>Mol Plant Microbe Interact</ISOAbbreviation></Journal><ArticleTitle>Single amino acid changes in the 6K1-CI region can promote the alternative adaptation of Prunus- and Nicotiana-propagated Plum pox virus C isolates to either host.</ArticleTitle><Pagination><MedlinePgn>136-49</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1094/MPMI-08-13-0242-R</ELocationID><Abstract><AbstractText>Plum pox virus (PPV) C is one of the less common PPV strains and specifically infects cherry trees in nature. Making use of two PPV-C isolates that display different pathogenicity features, i.e., SwCMp, which had been adapted to Nicotiana species, and BY101, which had been isolated from cherry rootstock L2 (Prunus lannesiana) and propagated only in cherry species, we have generated two infective full-length cDNA clones in order to determine which viral factors are involved in the adaptation to each host. According to our results, the C-P3(PIPO)/6K1/N-CI (cylindrical inclusion) region contains overlapping but not coincident viral determinants involved in symptoms development, local viral amplification, and systemic movement capacity. Amino acid changes in this region promoting the adaptation to N. benthamiana or P. avium have trade-off effects in the alternative host. In both cases, adaptation can be achieved through single amino acid changes in the NIapro protease recognition motif between 6K1 and CI or in nearby sequences. Thus, we hypothesize that the potyvirus polyprotein processing could depend on specific host factors and the adaptation of PPV-C isolates to particular hosts relies on a fine regulation of the proteolytic cleavage of the 6K1-CI junction. </AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Calvo</LastName><ForeName>María</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Malinowski</LastName><ForeName>Tadeusz</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>García</LastName><ForeName>Juan Antonio</ForeName><Initials>JA</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Mol Plant Microbe Interact</MedlineTA><NlmUniqueID>9107902</NlmUniqueID><ISSNLinking>0894-0282</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018076">DNA, Complementary</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012367">RNA, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014764">Viral Proteins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D019943" MajorTopicYN="N">Amino Acid Substitution</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018076" MajorTopicYN="N">DNA, Complementary</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016679" MajorTopicYN="N">Genome, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058507" MajorTopicYN="N">Host Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018515" MajorTopicYN="N">Plant Leaves</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017801" MajorTopicYN="N">Plum Pox Virus</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D027861" MajorTopicYN="N">Prunus</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012367" MajorTopicYN="N">RNA, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014026" MajorTopicYN="N">Tobacco</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014764" MajorTopicYN="N">Viral Proteins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>11</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>11</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>4</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24200075</ArticleId><ArticleId IdType="doi">10.1094/MPMI-08-13-0242-R</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Calvo, Maria" sort="Calvo, Maria" uniqKey="Calvo M" first="María" last="Calvo">María Calvo</name><name sortKey="Garcia, Juan Antonio" sort="Garcia, Juan Antonio" uniqKey="Garcia J" first="Juan Antonio" last="García">Juan Antonio García</name><name sortKey="Malinowski, Tadeusz" sort="Malinowski, Tadeusz" uniqKey="Malinowski T" first="Tadeusz" last="Malinowski">Tadeusz Malinowski</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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